Statins Prostate Cancer Diet Acrylamide Cancers of the
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These drugs lower elevated cholesterol levels by blocking a key enzyme necessary for cholesterol production in the body, and have been shown to reduce the risk of heart attack and other cardiovascular events in multiple large studies. Some clinical research studies have suggested that statins may also reduce the risk of developing some cancers, perhaps due to their known anti-inflammatory effects. While the scientific jury is still definitely out on the topic of statins and cancer risk, three interesting new papers, just published in the journal Cancer Epidemiology, Biomarkers Prevention, assess the potential clinical impact of statins on the risk of developing prostate cancer.
A total of 888 new cases of prostate cancer were diagnosed among these study participants during the 2002 to 2004 timeframe of this clinical study. Among the men who had been taking statin drugs for less than 5 years, there was no apparent reduction in prostate cancer incidence when compared to a matched group of men who were not taking these cholesterol-lowering medications. However, among the cohort of men who had been taking statins for 5 or more years, a 28% reduction in the incidence of prostate cancer was observed. Unfortunately, this association between statins and a reduced risk in the incidence of prostate cancer only appeared among men who were also taking anti-inflammatory medications known as nonsteroidal anti-inflammatory drugs (this class of drugs includes aspirin, ibuprofen, and naproxen, among several others, many of which are now available over the counter; and the now highly restricted prescription drugs Vioxx and Celebrex).
The results of this study, unfortunately, do not confirm a favorable association between statin medications and the risk of prostate cancer, as the nonsteroidal anti-inflammatory class of drugs are known to be potent cancer preventive agents in their own right (especially for precancerous colon and rectal polyps).
Unlike prospective, randomized clinical trials, where one matched group of study participants all receive one medication or treatment, while another matched group receives only a placebo or another alternative treatment, observational studies almost always suffer from an inescapable level of uncertainty regarding the true relationship between the variables studied (in this case, the use of statins, and their duration of use) and the outcomes observed (the incidence of prostate cancer, in this study).
So, based upon this study alone, one would be hard-pressed to conclude that the use of statin drugs is associated with a significant reduction in the risk of prostate cancer.
The second study, from the Finnish Cancer Institute, reviewed all cases of prostate cancer diagnosed in Finland between 1995 and 2002, and then matched these prostate cancer cases with men of similar ages who had not been diagnosed with prostate cancer, for a total of almost 25,000 individuals. As in many countries with a socialized healthcare system, the authors were able to review the prescription records of all of the men involved in this study, including the use of statin drugs. Unfortunately, there did not appear to be any overall reduction in the incidence of prostate cancer among the men who were prescribed statin drugs. However, the risk of presenting with advanced prostate cancer appeared to be lower among men who had taken atorvastatin, lovastatin or simvastatin, but not any of the other statin drugs in use in Finland during the period of this study.
Finally, the third study, from the American Cancer Society, looked at a large database from the Cancer Prevention Study II Nutrition Cohort study. More than 55,000 men in this study were evaluated, and as with the prior two studies, looking for an association between statin use and the incidence of prostate cancer. As with the Finnish and Kaiser Permanente studies, this epidemiological study did not find any association between statin use and the incidence of prostate cancer, overall, although, as with the Finnish study, there did seem to be a modest reduction in the incidence of advanced cases of prostate cancer, at presentation, among the patients using statin medications for 5 or more years.
Taken together, these three large epidemiological studies do not appear to reveal any beneficial effect of statin medications on the risk of developing prostate cancer, although, perhaps, statins might decrease the likelihood of being diagnosed with a more advanced stage of prostate cancer. As with so many other important clinical questions, the final word on this topic awaits mature data from large, randomized, blinded, placebo-controlled clinical trials.
DIETARY ACRYLAMIDE RISK OF CANCERS OF THE UTERUS, OVARY BREAST
The role of dietary factors in cancer development is an area of intense interest and ongoing research.
A new study, published in the journal Cancer Epidemiology, Biomarkers Prevention, evaluated the dietary intake of acrylamide in a large public health study that is tracking the association of diet with the incidence of cancer in the Netherlands. Almost 2,600 study participants (out of a total of more than 62,000 adult women study participants) were randomly chosen for the study of acrylamide intake and cancer risk. Combining data from dietary surveys and cancer histories in this study population, as well as the results of chemical analyses of Dutch foods for acrylamide content, this epidemiological study followed this group of women for just over 11 years. Importantly, smokers participating in this trial were identified up front, as tobacco smoke contains significant amounts of acrylamide as well. When the smokers were eliminated from the statistical results, high dietary levels of acrylamide were found to be associated with double the risk of developing uterine and ovarian cancer when compared to study volunteers with the lowest amount of acrylamide in their diet. No association between acrylamide intake and breast cancer was observed, however.
Dutch study, which was highly dependent upon the accuracy of dietary surveys completed by study participants), whether or not the observed relationship between high acrylamide intake and cancers of the uterus and ovaries reveals a true cause-and-effect mechanism, versus a mere observational association, cannot be completely verified by studies such as these.
A new study from Europe, just published in the journal Circulation, studied the effects of dark chocolate in patients who had previously undergone a heart transplant. Dark chocolate, unlike its fat- and sugar-loaded cousin milk chocolate, is rich in antioxidants collectively known as flavonoids. These compounds are though to interrupt the metabolic mechanisms, including inflammatory pathways, underlying the development of atherosclerosis. When the arteries that nourish the heart (coronary arteries) become severely clogged with atherosclerotic plaques, angina and heart attacks are often the result.
When an injury in the body occurs, these tiny cells clump together and form a plug-like matrix upon which blood clots can form. Unfortunately, when the lining of our coronary arteries become damaged by atherosclerosis, platelets can begin to stick onto these atherosclerotic plaques, which can lead to a sudden and complete blockage of the small coronary arteries. This is thought to be the mechanism whereby most heart attacks are generated, and it is the primary reason why aspirin, which impairs platelet function, is used to prevent and treat heart attacks.
In the heart transplant patients who ate dark chocolate two hours before testing, the coronary artery dilation response was much more robust than was seen in the patients who ate the placebo chocolate. In fact, there was no change in arterial dilation observed in the patients who ate the fake chocolate.
Taken together, the findings of this interesting little study suggest that dark chocolate, unlike its tastier relative, milk chocolate, may have some beneficial impact on cardiovascular function. A long-term prospective, randomized clinical trial involving non-transplant volunteers at high risk for coronary artery diseases is now needed to further assess the potential benefits (and side effects) of dark chocolate, as well as to study the optimum amount (if any) of dark chocolate that should be incorporated into a heart-healthy diet.
Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity
Dr. Wascher is an oncologic surgeon, professor of surgery, and a widely published author. He is the Director of the Division of Surgical Oncology at Newark Beth Israel Medical Center.
Send your feedback to Dr. Wascher at rwascher@doctorwascher.
MensNEWSdaily , mndnet.com, BlogWonks.com , BlogWonk.com , NewsWax.com , YakVox.com , DorkWatch.org , CounterPulse.com , JavaKing.com 2001 - 2006 Java King, Inc.. Opinions found on this website are expressly those of the author(s) and do not necessarily reflect the opinion of this publication, its editorial staff or contributors.
You were obese? You are gastrointestinal discomfort, inflammation and indigestion problems? Why do you even can not strict dieting weight down? Why is it that some people balanced nutrition, and regular exercise can be more or ill disaster? The latest research shows that scientists, the answer to all the questions in people s blood type, that is, your blood type does not match with recipes blame misfortune.
Originally, all kinds of food contain different phytohemagglutinin, phytohemagglutinin with your blood group antigens can be compatible health promotion, the opposite will happen if the various abnormal reactions, damage red WBC, gradually cause various problems, gastro-intestinal damage, nervous system and other organ functions. Research has proven that, if the Food and phytohemagglutinin your blood type matching, can produce good effects, such as swelling, anti-toxins, maintaining ideal body weight, such as aging. Therefore, the blood type diet In recent years scientists popular concern.
Type O blood: the digestive organs such ability, with a surplus of food to respond to the immune system, so most recipes is not the lack of animal proteins, such as meat and fish, and so on. However, the meat should be mainly lean meat, less fat James Edge. As for the fish, cod, herring and other fish and blue-and-white in the North Sea produced by the fish with more fat most worthy of recommendation. And usually the bread and cereal category are advised to eat less food, because these foods in the exogenous lectin would impede the metabolism of type O blood, so that you unconsciously fat together.n
A blood type: O-type blood and the people of comparison, A-type blood to the digestive organs were much weaker, so the blood type A people to lose weight, vegetables on the table should play a leading role in the most important soybean products, particularly tofu not lack. Protein best choice plants, eat meat as food. In addition, butter and all kinds of cheese, ice cream, milk and other raw materials to produce pure milk for food should also be restricted.n
B-type blood: O, A two-person compared to the B-type blood in the human body more balanced, with strong immune system. Such a body stronger, heart disease and cancer, and many other modern disease resistance. In the area is richly endowed by nature to eat, whether animals or plants can be like eating almost unlimited. Of course, with lean meat or meat, cod, salmon, and other better. While olive oil is excellent. As for the potatoes, buckwheat, peanuts, sesame and wheat, and so on, can type B blood metabolic efficiency of the people will eat food in the form of fat stored up. In addition, shrimp, crab and chicken, also contain type B blood on the harmful exogenous lectin, it is avoided as far as possible is the best. While corn, corn pie, lentils, peanuts, sesame seeds, wheat, bread, biscuits, etc.n
Blood type AB: This is the type A and type-B blood mixed blood type, diet and environmental changes can alter. But because relatively weak digestive organs, basically type A and type-B blood of the people should not eat food, AB also is unfit for human consumption. AB blood type most suitable for people to eat protein meat is mutton, eggs and fish shellfish, in particular snail meat, and the role of prevention of breast cancer. In addition, the tofu is good food, but then it is fresh.
Related: Statins Prostate Cancer Diet Acrylamide Cancers of the
Additional information:
From mensnewsdaily.com:
Your blood type is the key to a more personalized approach to diet, supplements. You love the Blood Type Diet and want to tell everyone.
Medical experts universally agree that the theory is nonsense, and say there is absolutely no link between our blood group and the diet we eat.
Following a blood group diet may help you lose weight, as each of the plans for the four blood types eliminates specific groups of food such as bread and.
Can at times be attributed to a particular blood group. The ultimate Achilles heel of the Blood Type Diet lies in the fact that most medical.
Blood Type Diet So you have decided that you want to change your eating habits to lose weight and live a healthier life. Of course, there is the question.
So, the first critical component of the blood type diet revolves around the question of which foods your blood type ancestors.
Free advice on the blood group diet and many other forms of dieting.
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