Small firm s fen-phen-like obesity drug shows promise

BOSTON -- Arena Pharmaceuticals Inc. has bet it can develop a drug from the same family as the notorious diet pill combination fen-phen -- and the gamble may be paying off.

Arena, with a market value of just $465 million, is convinced it can make its obesity drug work without causing the heart damage associated with fen-phen.

And on Monday, San Diego-based Arena said an interim safety review of a trial of the drug, lorcaserin hydrochloride, showed that it caused no heart safety problems after 12 months.

"This is huge," said Dr. Bryan Roth, a psychiatrist at the University of North Carolina who specializes in drug actions and side effects. "This is the big thing everyone was waiting for, and my guess is it will encourage other companies with similar compounds at earlier stages of development to move them along quickly."

Fen-phen combined Wyeth's drugs Pondimin and Redux with the stimulant phentermine to create a popular cocktail that stands out as one of the most costly failures in drug history.

Pondimin and Redux, also known as fenfluramine and dexfenfluramine, were withdrawn more than a decade ago, but Wyeth, which has spent billions of dollars over the years to settle legal claims, has only recently been able to put the issue behind it.

Roth, who has no financial ties to Arena, is more familiar than most with the fen-phen story and was the first to try to figure out why fenfluramine caused heart valve damage.

"No one was interested in finding out why the drug was toxic," he said. "People just wanted to run from it."

After considerable research, Roth and other researchers developed the theory that the problem with fenfluramine was that it activated a cellular receptor known as 5-HT2b.

The 5-HT2b receptor is closely related to a receptor known as 5-HT2c, which is known to suppress appetite and is also activated by fenfluramine. Roth hypothesized that 5-HT2b was the culprit behind cardiovascular problems.

That theory gained some validity last year when U.S. health officials withdrew a drug called pergolide that was developed by Eli Lilly and & Co. Pergolide too activates the 5-HT2b receptor.

Arena's drug selectively targets 5-HT2c. Although it may also hit 5-HT2b, so far it does not appear to cause problems.

Athersys Inc., which has a market capitalization of about $67 million, claims its similar drug is even more selective. That drug is at an earlier stage of development than Arena's.

Shares of Cleveland-based Athersys rose 15 cents, or 4.2%, to $3.70, while shares of Arena climbed 23 cents, or 3%, to $6.54.

TrueCurve (Shu Gefen) by the United States more than medical Lishou east herbs researchers Raodao years of research bent. Extraction of the application of life skills to cut palm fruit, angelica root, 10 Dingding yam herbal botanical extracts. Special formula, excluding any western medicine, qualified the United States FDA standards. Being recognized is the first American plant

R D products, Shu Gefen contained in the various top things element in the masses of the breast throughout, preaching cell vitality has Ti Ran Wei Ji, Top things to promote breast swelling awkward, it is also the supply of breast-dimensional defense and security, recalls breast nutrition, strengthen connective hooks painted help shaping performance, so breast-shaped quasi-Qiu missing

The goods are built by the United States, is original imports in the United States have been a violation of the ancient 78. Product hardline elements Saw palm fruit, angelica root, Mesopotamia, the leaves, fenugreek seeds, St. thistle, fennel, yam, the Americas 10 Dingding Pukui fruit extract of the herb. Special formula, does not contain any western medicine, qualified the United States FDA standards, the Taipei City Bureau of Health tests. Therefore, we have a strong moral protection. On the human body without any adverse factors, and was not the phenomenon has rebounded.

TrueCurve (Shu Gefen)

Weiji, and the remaining approximately 10% of the two needs months or longer to see Weiji. A considerable number of users or even three days a week and have minimal pain by up know. Beyond the 25-year-old women should be on the body, especially to the chest implementation of the general tone, delay aging, securing Miu Ling Nethersole scenes. Do not make a fuss about only in the face, chest general tone of your permanent treasure gratifying, awkward as a twig. Shu Gefen direct role in the lipid composition of the breast cells, nutritional prospects to learn from the fat cells succeeded fullness collapse --- --- proliferation of scenes, and to nourish breast suspensory ligament, the return of breast connective hooks painted flexibility so that the breast short of becoming the most strong in abundance, rounded.

Many women and the increased use of TrueCurve Volumizer (Shu Gefen) will have one month after the chest and increasing abundance of view, the first set of data is Chenbian say in the selection of 500 persons, many of them in Hsu continued use of the 3 months prospects have made increasing Weiji.

Syndrome chest by the former development of women is not due to the female hormones and physiological value eccentric eccentricity value produced hormone secretion, TrueCurve (Shu Gefen) not only frozen the chest can also increase by cutting before the female menstrual Yusang.

Easily crowd (1) of the gonad (ovary) secretion caused by unmarried performance shortcomings of breast dysplasia, breasts flat, petite.

(2) thin body, breasts not Volumizer Guhan model type (type of pituitary performance hyperthyroidism) tall, regardless of prenatal and post-natal.

(3) the devaluation of the effectiveness of post-natal anterior pituitary.

(4) women breast-feeding prospects because of the vital nutrients in the many missing, beyond shortcomings, leading to breast showed foam, ptosis, shrinking population.

(5) Chest has been very good, I would like to better the crowd, using this product can do general breast enhancement, nourishment Bust Beauty, health care purposes.

(6) had mastitis history, but has been compacted over four seasons, can be used as a breast enhancement, Bust Beauty use.

Taking TrueCurve (Shu Gefen) should be concerned with the following issues:

1. Goods only for the healthy people beauty, health purposes, used as standard treatment for medical needs.

2.20 young female under the age of the use of this product should be intercepted in order to physically mature.

3. Female receptor of the ovaries, uterus, breast cancer, hyperplasia or unless tumor patients and during pregnancy, breast-feeding women in the use of intercept.

4. Done in the use of hormone replacement therapy or oral administration of hormonal contraceptives

Know how to use his body a reflection of a drug. If the use of the body to feel tighter, pharmacodynamics attack, continuous use.

2. If the use of small, feel pain or breast Ting change is potent attack, continuous use! At the same time increase the tempering of the chest.

3. In January, if you feel changes in breast shape, for the use of, at least in June, we will cherish the new shape of your breasts.

If the use of special identification of women chest than abundance, Weiji will be more eye-catching.

1. If the use of petite or tall women build healthy (and non-bone thin). Take 15-30 days, so that the breast change Ting, anti-ease.

2. In the February-March period, an increase of breast 4-June period, a continuing memories.

3. If women are bone thin, their hands Weiji very valuable, because only a desired fat enough ability to succeed

Weiji.

4. Breast increasing degree of personal follow specific intelligence individual, if the abundance of women in the chest, a week can increase 1.5-2.5 inches.

5. Women if ovarian removal, in January, it could take two every day.

6. Goods not only for the breast enhancement, can also be used for the selection of hormones, skin, hair and bone composition of the staff such as high calcium treatment.

7. Some women will trigger menstruation delay, extend, such as tightening of view, this is healthy treat blood body color that she s tough situation.

8. Weight of the goods will not show excess Weiji, it will enable the use of the female body more dilute efforts to Dingjing use.

Benpinwei health food, drug prevention alternative therapeutic role. Effects: 1, the heavily

Weiji;

2, the transfer of menopause on the role;

3, the top issue of endocrine regulation;

4, as an aging of the skin wrinkles have anti-wrinkle agent;

5, Ti ran the Chidouweiji;

6, in Muning relaxation of women to prevent osteoporosis and cardiovascular disease;

7, can fuel the blood circulation;

8, can promote appetite, ease good sleep seizures;

9, Soul Jueyue, restitution Miu Ling Nethersole medicine;

10, cataract symptoms can help by cutting staff impression of the treatment can exceed the physical and depreciation, and to make physical activity more intelligence.

Specifications: 60, per 600 mg.

Usage dosage: After breakfast and bedtime each taking one from the first day of the first menstrual period consumption, taking 15 days, as food for 15 days. Then the first of a cycle and then 15 days of consumption, the deadline for 15 days. The first to the second cycle, and need not have to ponder whether the first day of menstruation. And so on. Advocate taking more than three months.

Ingredients: Saw palm fruit, angelica root, Mesopotamia, the leaves, fenugreek seeds, St. thistle, fennel, yam, the Americas 10 Dingding Pukui fruit herbal botanical extracts.

Concerns: the combination of high calcium foods such as milk, Weiji better, and calcium can be combined; not take foods containing caffeine or alcohol, in order to protect their beneficial function and tough. Following this intelligence we do not advocate taking TrueCurve (Gefen Shu):

A. b. myocardial debilitating cerebral vascular disease d. c. acute liver disease had been suffering from breast cancer of the uterine cancer Ancient e. f. unknown ago bleeding g. h. vascular obstruction of thyroid abnormalities in the estrogen i. Ji absorbed by the combination was diagnosed with cancer (estrogen combination mildly ovarian, uterine and / or breasts, etc.) j. lactating pregnant k. l. stiff hypertension m. stiff liver n. gallbladder disease have had vascular o. prejudice to the transcript p. diabetes and pancreatitis q. high cholesterol r. Migraine s. epilepsy, epilepsy wind sheep cervical erosion u. t. v. hyperthyroidism physical comparison of w. Shengkong ovarian cyst x. uterine fibroids y. Breast fibroma.

Additional information :

From www.latimes.com:
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